利用CuO-ZnO-Al₂O₃催化剂对己二酸二甲酯催化加氢制1，6-己二醇低压工艺进行研究。采用单因素实验法探究了反应压力、液时空速、反应温度、氢酯摩尔比对反应的影响。并采用Box-Behnken Design对加氢工艺进一步优化。在3 MPa条件下，以反应温度、液时空速、氢酯摩尔比为变量，以1，6-己二醇收率为响应值，建立回归方程。响应面优化后确定的最优工艺条件为：反应温度为204.2℃、液时空速为0.206 h^-1、氢酯摩尔比为120，该条件下1，6-己二醇收率可达97.71%。

The self-made CuO-ZnO-Al₂O₃ catalyst is used to study the catalytic hydrogenation of dimethyl adipate to 1, 6-hexanediol under low pressure.The influences of pressure, liquid hourly space velocity, reaction temperature, and the molar ratio between hydrogen and dimethyl adipate on the reaction are investigated via single factor experiment.Based on single factor experiments, Box-Behnken Design software is utilized to optimize the hydrogenation process.A regression equation is established at 3 MPa with reaction temperature, liquid hourly space velocity, and the molar ratio of hydrogen to dimethyl adipate as variables, and 1, 6-hexanediol yield as the response value.The optimal process conditions at 3 MPa are finally obtained after response surface optimization that reaction temperature is at 204.2℃, liquid hourly space velocity is 0.206 h^-1, and the molar ratio of hydrogen to dimethyl adipate is 120.Under these conditions, the yield of 1, 6-hexanediol can reach 97.71%.

弓浩宇(1997-),男,硕士研究生,主要从事反应工程与绿色化工研究,13949021629@163.com