介绍了2021年美国（总统）绿色化学挑战奖获奖项目的概要、创新与价值。5个奖项的获奖者分别是：绿色合成路线奖授予默克公司，贡献在于合成了吉法匹生柠檬酸盐（Gefapixant Citrate）；绿色反应条件奖授予百时美施贵宝公司，贡献在于其开发的5种可持续试剂；设计绿色化学品奖授予Colonial Chemical公司，他们开发了Suga^® Boost表面活性剂；小企业奖授予XploSafe有限责任公司，他们开发了新型吸附剂PhosRox；学术奖授予克莱姆森大学，其贡献在于非异氰酸酯聚氨酯（NIPU）泡沫的研发。

The overview, innovation and benefits of award-winning projects of 2021 US Green Chemistry Challenge Awards are introduced.Merck & Co., Inc.receives Greener Synthetic Pathways award by developing a green and sustainable manufacturing process for Gefapixant Citrate.Greener Reaction Conditions Award is won by Bristol Myers Squibb for developing five sustainable reagents.Designing Greener Chemicals award is obtained by Colonial Chemical for developing environmentally friendly, high performing Suga^® Boost surfactants.XploSafe LLC is the winner of Small Business award because creating PhosRox, a novel sorbent used to make fertilizer.Professor Srikanth Pilla of Clemson University wins the Academic award for creating the first nonisocyanate polyurethane foam.