VAH-type aldehyde hydrogenation catalyst is applied in a 50000 tons per year isopropanol plant in Qingdao, China for the first time. Calibration results show that the conversion rate of acetone reaches 99.78% and the selectivity of isopropanol reaches 99.68% under a 105.6% of feeding load. Plant tracking results show that the hot spot in the catalyst bed moves up slowly, and the yield of isopropanol remains stable and has always been higher than 99.0 wt%.