以木薯淀粉为原料，用微波-超声波辅助沉降法制备淀粉纳米颗粒，通过扫描电镜、粒度仪等对淀粉纳米颗粒进行了表征。以姜黄素为载药模型，考察了药物初始质量浓度、无水乙醇质量分数、载药温度、载药时间对载药量的影响，并探究了木薯淀粉纳米颗粒对姜黄素的缓释作用。结果表明，药物初始质量浓度为40 μg/mL、无水乙醇质量分数为30%、载药温度为30℃、载药时间25 min时，木薯淀粉纳米颗粒对姜黄素的吸附量最大，可达81.14 mg/g。姜黄素原料药5 h释放率为95%，而木薯淀粉纳米颗粒透析5 h后，药物释放率仅为15%。由此可知，微波-超声波辅助沉降法制备的木薯淀粉纳米颗粒具有较好的载药性能，并对药物具有较好的缓释效果。

Starch nanoparticles are prepared from tapioca starch by using microwave-ultrasonic assisted sedimentation method,and characterized by scanning electron microscopy and particle size analyzer.Curcumin is used as drug model to evaluate the effects of initial drug concentration,absolute ethanol concentration,drug loading temperature and drug loading time on drug loading amount of the starch nanoparticles.The sustained-release effect of starch nanoparticles on curcumin is also investigated.It is found that the adsorption amount of curcumin by the tapioca starch nanoparticles reaches the highest,81.14 mg·g^-1 when the initial concentration of the drug is 40 ug·mL^-1,the mass concentration of absolute ethanol is 30%,the drug loading temperature is at 30℃,and the drug loading time is 25 min.The release rate of curcumin reaches 95% in 5 h,while the drug release rate is 15% only after dialysis on the tapioca starch nanoparticles loaded drug have been performed for 5 h.It can be seen that the tapioca starch nanoparticles prepared by the microwave-ultrasonic assisted sedimentation method have good drug-loading properties and have a good sustained-release effect on the drug.

寇宗亮(1993-),男,硕士研究生,主要研究方向为生物基材料,uniqueKZL@163.com