探究离子液体与银杏叶中黄酮类化合物的作用关系，筛选可以显著提高银杏叶中黄酮类化合物提取量的离子液体，并利用该离子液体与醇提法、微波-超声联合的新型提取方法提取银杏叶中总黄酮，探究最佳实验条件，并用响应面的方法优化实验条件。得到的最佳实验条件为：离子液体为0.75 mol/L[Bmim]Glu，超声功率为69 W，超声时间为6.5 min，微波时间2 min，最佳提取量为41.34 mg/g，响应面与实际值相差0.33%。最佳实验条件下，提取量达到传统方法提取量的4倍，提取时间缩短为传统提取方法的1/10，该方法操作方便、快捷、可靠。

The action relationship between ionic liquid and the flavonoids in Ginkgo biloba leaves is explored to screen an ionic liquid that can significantly increase the extraction amount of flavonoids from Ginkgo biloba leaves.This ionic liquid combined with alcohol extraction and microwave-ultrasonic extraction together is used in extraction of flavonoids from Ginkgo biloba leaves.Response conditions are used to optimize the experimental conditions.The optimal experimental conditions obtained are as follows:the content of [Bmim] Glu ionic liquid is 0.75 mol·L^-1,ultrasonic power is 69 W,ultrasonic acts for 6.5 min and microwave acts for 2 min.The optimal extraction amount is 41.338 4 mg·g^-1,and the response surface is 0.33% different from the actual value.Under the optimal extraction conditions,the extraction amount by this method is 4 times that by the traditional method,and the needed extraction time is shortened to one tenth that the traditional extraction method needs.The operation is convenient,fast and reliable.

冯靖(1993-),女,硕士研究生,研究方向为天然产物分离及中药学,1030482679@qq.com