利用加速溶剂萃取法（ASE）萃取污泥中合成麝香（SMs），石墨化炭黑和佛罗里硅藻土在线净化，经HP-5MS毛细管柱分离，建立了气相色谱-串联质谱法（GC-MS/MS）同时测定污泥中12种SMs残留量的分析方法。结果表明，12种SMs在0.01~1.0 μg/mL质量浓度范围内呈良好线性关系，相关系数（r²）为0.999 6~0.999 9；该方法检出限为1.5~3.0 μg/kg，定量限为5.0~10.0 μg/kg，回收率为91.5%~98.8%，相对标准偏差为0.9%~2.8%。老化效应、基质效应对ASE萃取污泥中12种SMs的影响较小。该方法具有检出限低、回收率高、精密度好等特点。

Synthetic musk (SM) in sludge is extracted by accelerated solvent extraction (ASE),purified on-line by graphitized carbon black and Florian diatomite,and separated by HP-5MS capillary column.A method for the simultaneous determination of 12 kinds of SM residues in sludge by gas chromatography tandem mass spectrometry (GC-MS/MS) is developed.The results show that 12 kinds of SM show a good linear relationship in the concentration range of 0.01-1.0 μg·mL^-1,with correlation coefficient ranging from 0.999 6 to 0.999 9.The detection limits range from 1.5 μg·kg^-1 to 3.0 μg·kg^-1 and the quantization limits range from 5.0 μg·kg^-1 to 10.0 μg·kg^-1.The recovery rates range from 91.5% to 98.8% and the relative standard deviations range from 0.9% to 2.8%.Aging effect and matrix effect have little impact on extraction of 12 kinds of SM in sludge by ASE.This method features with low detection limit,high recovery rate and good precision.