以二甲基亚砜为原料，过氧化氢为氧化剂，研究了在脉冲混合结构微通道反应器中氧化合成二甲基砜的连续流工艺。考察了反应物料配比、过氧化氢质量分数、反应停留时间、反应温度等对反应的影响。结果表明，当n（二甲基亚砜）∶n（过氧化氢）=1∶1.5、过氧化氢质量分数为50%、反应温度为130℃、反应停留时间为10 min时，二甲基亚砜完全氧化成二甲基砜。此工艺充分利用微通道反应器优良的传质传热特点，大大缩短了反应时间，提高了反应速率，扩大了工艺条件选择区间，实现了对氧化反应过程的有效控制，增加了安全系数。

Using dimethyl sulfoxide as raw material and hydrogen peroxide as oxidant,a continuous flow process for the oxidative synthesis of dimethyl sulfone in pulsed hybrid microchannel reactors is developed.The effects of ratio of reactive materials,concentration of hydrogen peroxide,residence time and reaction temperature on the reaction are investigated.The optimum process results show that dimethyl sulfoxide is completely oxidized into dimethyl sulfone when n(dimethyl sulfoxide):n(hydrogen peroxide)=1:1.5,the concentration of hydrogen peroxide is 50%,the reaction temperature is set at 130℃ and the reaction residence time is 10 min.This process makes full use of the excellent mass transfer and heat transfer characteristics of the microchannel reactor,shortening greatly the reaction time,increasing the reaction rate,expanding the selection of process conditions,realizing effective control on the oxidation reaction process,and increasing the safety factor.

薛鹏博(1993-),女,硕士生