以甲基丙烯酸丁酯为功能单体，二甲基丙烯酸乙二醇酯为交联剂，正丙醇和聚乙二醇400为致孔剂，偶氮二异丁腈为引发剂，在不锈钢管模具中制备聚合物整体柱（BMA-co-EDMA）；以BMA-co-EDMA柱为萃取介质，利用聚合物整体柱微萃取技术，结合液相色谱-串联质谱法（LC-MS），建立了同时测定工业废水中6种喹诺酮药物残留量的分析方法。结果表明，在0.2~100.0 ng/mL质量浓度范围内，各目标物定量离子峰面积与其质量浓度呈现良好线性关系，相关系数在0.999 6~0.999 9之间，检出限在0.07~0.35 ng/L，定量限在0.2~1.0 ng/L，回收率在92.3%~98.6%，相对标准偏差在0.7%~3.7%。与其他方法相比，BMA-co-EDMA柱稳定性和重现性良好，可反复使用10次以上。

A polymer monolithic column is prepared in a stainless steel tube mold with butyl methacrylate as functional monomer,ethylene glycol dimethacrylate as crosslinking agent,n-propanol and polyethylene glycol 400 as porogen,and azo-bis-isobutyronitrile as initiator.The method to determine simultaneously 6 kinds of quinolones residues in industrial waste is developed by polymer monolithic microextraction combining with LC-MS through using BMA-co-EDMA column as extractive medium.The results show that the peak area of quantitation ion of each target substance shows a good linear relationship with its concentration in the range of 0.2-100.0 ng·mL^-1,with correlation coefficient ranging from 0.999 6 to 0.999 9.The detection limits range from 0.07 ng·L^-1 to 0.35 ng·L^-1.The quantitation limits range from ng·L^-1 to 1.0 ng·L^-1.The recovery rates range from 92.3% to 98.6%,and the relative standard deviations range from 0.7% to 3.7%.Compared with other methods,BMA-co-EDMA column has good stability and reproducibility,which can be used repeatedly more than 10 times.