利用单因素法分别以氯化钙、氯化锌为交联剂，载荷吲哚美辛，复合十二烷基甜菜碱与果胶制备凝胶球。考察十二烷基甜菜碱、药物和交联剂质量分数对小球的形态、载药量、包封率和在模拟胃肠道中释药性能的影响，并比较钙锌体系的释放性能。结果表明：添加十二烷基甜菜碱可以提高凝胶球的载药量和包封率，减缓药物释放；吲哚美辛质量分数过高时会导致凝胶球的释药性能变差；交联剂质量分数的增加使凝胶球性能均呈现增长的趋势。2个体系的释药性能研究结果显示，添加十二烷基甜菜碱对果胶锌体系的释药性能影响较大。

Gelatin beads are prepared via a single-factor method by using calcium chloride and zinc chloride as crosslinking agent respectively,and loading indomethacin and combining dodecyl betaine with pectin.The effects of the concentrations of dodecyl betaine,drug and crosslinking agent on the morphology,drug loadings,entrapment efficiency and the release performance in the simulated gastrointestinal tracts are explored.The release behaviors of calcium and zinc system are compared.The results show that the addition of dodecyl betaine can help gelatin beads to increase the drug loading and entrapment efficiency and slow down the release rate of drugs.When the content of indometacin is too high,the release performance of the beads will become worse.The increase of concentration of crosslinking agent shows a tendency to increase the release performance of gelatin beads.The results of the study on the release properties of these two systems show that the addition of dodecyl betaine has a great effect on the release performance of pectin zinc.

谭丽珠(1992-),女,在读硕士,研究方向为天然物提取与改性研究,13682106389@163.com