建立了加压液体萃取（PLE）-凝胶渗透色谱（GPC）净化-液相色谱-串联质谱法（LC-MS/MS）测定沉积物中8种性激素含量的方法。结果表明，8种性激素在10~1 000 μg/L范围内呈良好的线性关系，相关系数R² ≥ 0.999 6；检出限在10~100 μg/kg之间；加标回收率为85.6%~101.4%，RSD为0.8%~2.7%。该方法自动化程度高，灵敏度高，回收率好。

A method of pressurized liquid extraction (PLE) and gel permeation chromatography (GPC) purification and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of 8 kinds of sex hormone in sediments is established.The results show that these 8 kinds of sex hormone with concentration ranged from 10 μg·L^-1 to 1 000 μg·L^-1 show a good linear relationship with correlation coefficient R² not less than 0.999 6;the detection limits are in the range of 10 μg·kg^-1 to 100 μg·kg^-1;the recovery rates are in the range of 85.6% to 101.4%,the relative standard deviations (RSD) are ranged from 0.8% to 2.7%.The method has the advantages of high automation,high sensitivity and good recovery rate.