Abstract: 2,2-Dimethyl-3-chloropropanol (LBC),a by-product of ibuprofen production,can be used to manufacture 2,2-dimethyl-1,3-propylene oxide (HBM).Neopentyl glycol (NPG) can be made by the hydrolysis reaction with HBM as raw material and dilute sulfuric acid as catalyst.The effects of reaction temperature,sulfuric acid concentration and phase ratio of water to oil on the yield of NPG are investigated through orthogonal experiments.The results show that phase ratio has the greatest effect while sulfuric acid concentration and temperature has hardly effect.The effect of phase ratio is further studied through single factor experiments.The results show that the NPG yield increases rapidly and then becomes gradually flat with the increasing of the phase ratio.The relationship between the yield (Y) and the phase ratio (X) is Y=0.996 277-0.113 43/X+0.041 783ln(X/10)-0.003 246 8X.Simulation calculation and operation cost optimization for the reaction liquid concentration process are performed by using Aspen Plus software.The results show that the optimum phase ratio is 4 when single-effect distillation is used,the optimum phase ratio is 6 when double-effect distillation is used,and the operating cost of double-effect distillation is 29.0% lower than that of single-effect distillation.
郑磊, 岳金彩, 王宁, 郑世清. 2,2-二甲基-1,3-环氧丙烷水解制取新戊二醇工艺优化[J]. 现代化工, 2019, 39(4): 221-224.
ZHENG Lei, YUE Jin-cai, WANG Ning, ZHENG Shi-qing. Process optimization for preparing neopentyl glycol by hydrolysis of 2,2-dimethyl-1,3-epoxypropane. Modern Chemical Industry, 2019, 39(4): 221-224.
[1] 章意坚,陈延蕾,陈新志,等.新戊二醇合成与精制工艺的改进[J].化学反应工程与工艺,2006,22(2):185-188. [2] 吴文娟,孙卫中,戴成勇,等.甲醛和异丁醛缩合加氢合成新戊二醇的研究[J].化学世界,2015,56(1):42-46. [3] 吴树春,刘增业.新戊二醇的制备方法:CN,1301685A[P].2001-07-04. [4] Chen F,Zhang H,Bie L,et al.Studies on the anti-inflammatory drugs of 2-arylpropanoic acids 1.synthesis of ibuprofen by 1,2-aryl rearrangement[J].West China Journal of Pharmaceutcalences,1995,10(3):129-131. [5] Bertola M A,De Smet M J,Marx A F,et al.Process for the preparation of ibuprofen:US,5108917[P].1992-04-28. [6] 舒瑞友.布洛芬产品中重排工艺改进[J].药学研究,2006,25(4):242-243. [7] Kwon J T,Suciu G D.Saponification of chlorohydrins:US,4496753[P].1985-01-29. [8] 吕志果,郭振美,刘义勇.一种制备新戊二醇的方法:CN,102249853A[P].2011-11-23. [9] 刘义勇.2,2-二甲基-3-氯丙醇两步法制备新戊二醇研究[D].青岛:青岛科技大学,2010. [10] 李鑫钢,李学刚,李燕,等.乙醇-水体系双效精馏过程模拟[J].化工进展,2009,28(S2):374-377.