Synthesis of 1-(1-chloro-cyclopropyl)-3-(2-fluoro-phenyl)-2-(5-thio-2,5-dihydro-[1,2,4] triazole)-1-propanol
SHAN Jun, LV Xin-yu, QIU Tao
Jiangsu Provincial Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China
Abstract: In order to study a 1,2,4-triazole derivative with high biological activity that is similar with prothioconazole,1-chloro-1-chloroacetyl cyclopropane,a key intermediate for rothioconazole,is used as raw material to synthesis 1,2,4-triazole derivative through a four-step reaction including two-step nucleophilic substitution,reduction and electrophilic addition.The optimal reaction conditions are determined.Under the optimal reaction conditions,1-(1-chlorine-cyclopropyl)-3-(2-fluoro-phenyl)-2-(5-thio-2,5-dihydro-[1,2,4-trichlorobenzene] triazole)-1-propanol is synthesized.The overall yield counting on 1-chloro-1-chloroacetyl cyclopropane is 23.4%.
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