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现代化工  2018, Vol. 38 Issue (9): 127-131    DOI: 10.16606/j.cnki.issn0253-4320.2018.09.029
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
氧化石墨烯载药体系负载甲硝唑及体外释放的研究
张鑫1,2, 王永波1, 王林昕2, 刘恩周1, 胡晓云3, 樊君1
1. 西北大学化工学院, 陕西 西安 710069;
2. 陕西中医药大学药学院, 陕西 咸阳 712046;
3. 西北大学物理学院, 陕西 西安 710069
Research on metronidazole loaded on graphene oxide and their drug release in vitro
ZHANG Xin1,2, WANG Yong-bo1, WANG Lin-xin2, LIU En-zhou1, HU Xiao-yun3, FAN Jun1
1. School of Chemical Engineering, Northwest University, Xi'an 710069, China;
2. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;
3. School of Physics, Northwest University, Xi'an 710069, China
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摘要 通过改良的Hummers法制备了氧化石墨烯(GO),用GO负载抗菌药物甲硝唑(MTR),探讨了载药体系(GO-MTR)体外释放MTR的行为。GO经SEM、XRD、FT-IR和UV-Vis等表征表明,其褶皱较多、较薄,层间距为0.800 nm,具有石墨烯(001)晶面,在水中易分散,在紫外区230 nm有最大吸收;载药实验表明,增大负载体系的pH、升高温度均有利于GO吸附MTR,100 mL 1 mg/mL GO与0.500 g/L MTR等体积混合后,在pH为9.0、温度为40℃、振荡150 min的条件下,GO对MTR的负载量达494 mg/g,负载率为98.8%;释药研究表明,药物释放的突跃在8~36 h,释放时间较长,酸性体系有利于药物释放,pH为6时释药率可达58.7%。
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张鑫
王永波
王林昕
刘恩周
胡晓云
樊君
关键词:  氧化石墨烯  甲硝唑  药物负载  药物释放    
Abstract: Graphene oxide (GO) are prepared through the modified Hummers method.After characterized by SEM, XRD, FTIR and UV-Vis, the as-prepared GO is verified to have duplicated and paper-thin lamellar structure with an interplanar spacing of 0.800 nm and own the (001) crystal plane of graphene.The as-prepared GO is easy to disperse in water and exhibits maximum absorption at 230 nm ultraviolet region.The experiments that metronidazole (MTR) as antibacterial drug is loaded onto GO under different conditions indicate that the increases of both pH value and temperature of loading system are helpful for GO to load MTR;the loading amount and rate for MTR loaded by GO are 494 mg·g-1 and 98.8%, respectively when 100 mL of 1 mg·mL-1 GO is mixed with the same volume of 0.500 g·L-1 MTR to react under the conditions of pH 9.0, 40℃ and 150 mins of oscillating.Drug release in vitro experiments demonstrate preliminarily that the release of MTR from drug loading system to PBS solutions are easier within acidic system;the release jump of MTR occurs from 8 h to 36 h, and the maximum drug release percentage of GO-MTR can reach 58.7% at a pH of 6.0.
Key words:  graphene oxide    metronidazole    drug delivery    drug release
收稿日期:  2018-01-09      修回日期:  2018-07-04           出版日期:  2018-09-20
TQ460.1  
基金资助: 国家自然科学基金资助(21476183)
通讯作者:  樊君(1959-),男,博士,教授,博士生导师,研究方向为现代药物提取与分离,通讯联系人,fanjun@nwu.edu.cn    E-mail:  fanjun@nwu.edu.cn
作者简介:  张鑫(1978-),女,在读博士,实验师,研究方向为碳纳米材料载药,xinzhang715@yeah.net。
引用本文:    
张鑫, 王永波, 王林昕, 刘恩周, 胡晓云, 樊君. 氧化石墨烯载药体系负载甲硝唑及体外释放的研究[J]. 现代化工, 2018, 38(9): 127-131.
ZHANG Xin, WANG Yong-bo, WANG Lin-xin, LIU En-zhou, HU Xiao-yun, FAN Jun. Research on metronidazole loaded on graphene oxide and their drug release in vitro. Modern Chemical Industry, 2018, 38(9): 127-131.
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