Research on metronidazole loaded on graphene oxide and their drug release in vitro
ZHANG Xin1,2, WANG Yong-bo1, WANG Lin-xin2, LIU En-zhou1, HU Xiao-yun3, FAN Jun1
1. School of Chemical Engineering, Northwest University, Xi'an 710069, China; 2. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China; 3. School of Physics, Northwest University, Xi'an 710069, China
Abstract: Graphene oxide (GO) are prepared through the modified Hummers method.After characterized by SEM, XRD, FTIR and UV-Vis, the as-prepared GO is verified to have duplicated and paper-thin lamellar structure with an interplanar spacing of 0.800 nm and own the (001) crystal plane of graphene.The as-prepared GO is easy to disperse in water and exhibits maximum absorption at 230 nm ultraviolet region.The experiments that metronidazole (MTR) as antibacterial drug is loaded onto GO under different conditions indicate that the increases of both pH value and temperature of loading system are helpful for GO to load MTR;the loading amount and rate for MTR loaded by GO are 494 mg·g-1 and 98.8%, respectively when 100 mL of 1 mg·mL-1 GO is mixed with the same volume of 0.500 g·L-1 MTR to react under the conditions of pH 9.0, 40℃ and 150 mins of oscillating.Drug release in vitro experiments demonstrate preliminarily that the release of MTR from drug loading system to PBS solutions are easier within acidic system;the release jump of MTR occurs from 8 h to 36 h, and the maximum drug release percentage of GO-MTR can reach 58.7% at a pH of 6.0.
张鑫, 王永波, 王林昕, 刘恩周, 胡晓云, 樊君. 氧化石墨烯载药体系负载甲硝唑及体外释放的研究[J]. 现代化工, 2018, 38(9): 127-131.
ZHANG Xin, WANG Yong-bo, WANG Lin-xin, LIU En-zhou, HU Xiao-yun, FAN Jun. Research on metronidazole loaded on graphene oxide and their drug release in vitro. Modern Chemical Industry, 2018, 38(9): 127-131.
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