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现代化工  2018, Vol. 38 Issue (9): 50-53,55    DOI: 10.16606/j.cnki.issn0253-4320.2018.09.012
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纳米脂质药物偶联物的研究进展
刘丽萍, 王煜斐, 张亚洲
贵州理工学院食品药品制造工程学院, 贵州 贵阳 550003
Research progress on lipid drug conjugate
LIU Li-ping, WANG Yu-fei, ZHANG Ya-zhou
College of Food and Pharmaceutical Engineering, Guizhou Institute of Technology, Guiyang 550003, China
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摘要 综述了纳米脂质药物偶联物(lipid drug conjugate,LDC)的不同制备方法、表征手段及应用。纳米脂质药物偶联物基于脂质体系、纳米颗粒体系和脂质赋形剂形成良好的药物载体运输系统,有助于改善药物的渗透性和生物利用度。
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刘丽萍
王煜斐
张亚洲
关键词:  纳米药物  纳米脂质颗粒  脂质药物偶联物  制备    
Abstract: Lipid drug conjugate (LDC) is an active therapeutic agent for the combination of lipids such as fatty acids and phospholipids with drugs.It can be processed into nano-lipid drug conjugates, which can help to change the pharmacokinetic characteristics of the drug to achieve active targeted transport and reduce adverse reactions.The preparation methods, characterization measurements and applications of nano-lipid drug conjugates are summarized.
Key words:  nano drug    lipid nanoparticles    lipid drug conjugates    preparation
收稿日期:  2018-02-01      修回日期:  2018-07-04           出版日期:  2018-09-20
R318  
通讯作者:  张亚洲(1980-),男,博士,副教授,研究方向为纳米脂质药物及微胶囊,通讯联系人,zhangyazhou@git.edu.cn    E-mail:  zhangyazhou@git.edu.cn
作者简介:  刘丽萍(1985-),女,博士,高级工程师,副教授,研究方向为单分子检测技术的应用及太赫兹光谱学,shineliuliping@seu.edu.cn。
引用本文:    
刘丽萍, 王煜斐, 张亚洲. 纳米脂质药物偶联物的研究进展[J]. 现代化工, 2018, 38(9): 50-53,55.
LIU Li-ping, WANG Yu-fei, ZHANG Ya-zhou. Research progress on lipid drug conjugate. Modern Chemical Industry, 2018, 38(9): 50-53,55.
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http://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2018.09.012  或          http://www.xdhg.com.cn/CN/Y2018/V38/I9/50
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