Abstract: Gelatin beads are prepared via a single-factor method by using calcium chloride and zinc chloride as crosslinking agent respectively,and loading indomethacin and combining dodecyl betaine with pectin.The effects of the concentrations of dodecyl betaine,drug and crosslinking agent on the morphology,drug loadings,entrapment efficiency and the release performance in the simulated gastrointestinal tracts are explored.The release behaviors of calcium and zinc system are compared.The results show that the addition of dodecyl betaine can help gelatin beads to increase the drug loading and entrapment efficiency and slow down the release rate of drugs.When the content of indometacin is too high,the release performance of the beads will become worse.The increase of concentration of crosslinking agent shows a tendency to increase the release performance of gelatin beads.The results of the study on the release properties of these two systems show that the addition of dodecyl betaine has a great effect on the release performance of pectin zinc.
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