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现代化工  2018, Vol. 38 Issue (1): 129-132    DOI: 10.16606/j.cnki.issn0253-4320.2018.01.030
  科研与开发 本期目录 | 过刊浏览 | 高级检索 |
微流控法制备PLGA微球及其性能研究
陈红, 徐菊美, 赵世成, 岑莲
华东理工大学化工学院, 上海 200237
Preparation and characterization of PLGA microspheres by microfluidics method
CHEN Hong, XU Ju-mei, ZHAO Shi-cheng, CEN Lian
School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
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摘要 利用自行设计和制造的微流控两相和三相装置实现对聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]微球的可控制备,并对其性能进行研究,调控微流控操作参数,制备PLGA微球,并以传统乳化/溶剂挥发法作对照同时制备PLGA微球,对所得微球的形貌及粒径进行分析。结果表明,乳化/溶剂挥发法得到的微球分散性差,大小不均一,离散系数(coefficient of variation,CV)为44.13%,而微流控法得到的微球分散性极好,大小均一,且CV仅为2.73%(两相)和1.93%(三相),说明微流控法能够制备单分散性很高的PLGA微球,有着乳化/溶剂挥发法无法比拟的优势。
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陈红
徐菊美
赵世成
岑莲
关键词:  PLGA  微球  微流控法  可控制备  离散系数    
Abstract: The controllable preparation of poly(lactic-co-glycolic acid) (PLGA) microspheres is achieved by self-designed and self-made two-fluid-channel device and three-fluid-channel microfluidics device.The performance of PLGA microspheres is studied.The microfluidics parameters are adjusting and varying in the preparation process.PLGA microspheres are also prepared by traditional emulsion/solvent evaporation method,and are taken as a reference.Morphology and size distribution of the PLGA microspheres prepared by both methods are investigated.It is shown that PLGA microspheres prepared by emulsion/solvent evaporation method has serious aggregation and a wide size distribution with a coefficient of variation (CV) being 44.13%,whereas those prepared by two-fluid-channel microfluidics device and three-fluid-channel microfluidics device both have good dispersive performance,narrow size distribution,and CV of 2.73% (two-fluid-channel device) and 1.93% (three-fluid-channel device),respectively.It indicates that using microfluidics can manufacture highly mono-dispersive PLGA microspheres without aggregation.Hence,it is possible to achieve the precise control over the preparation of PLGA microspheres.
Key words:  PLGA    microspheres    microfluidics    controllable preparation    coefficient of variation
收稿日期:  2017-06-20                出版日期:  2018-01-20
TQ460.4  
通讯作者:  赵世成(1978-),男,博士,副教授,研究方向为高分子成型和加工,通讯联系人,zhaosc@ecust.edu.cn;岑莲(1978-),女,博士,教授,研究方向为生物材料化学工程,通讯联系人,liancen@ecust.edu.cn    E-mail:  zhaosc@ecust.edu.cn;liancen@ecust.edu.cn
作者简介:  陈红(1992-),女,硕士,研究方向为生物医用材料,1252327912@qq.com
引用本文:    
陈红, 徐菊美, 赵世成, 岑莲. 微流控法制备PLGA微球及其性能研究[J]. 现代化工, 2018, 38(1): 129-132.
CHEN Hong, XU Ju-mei, ZHAO Shi-cheng, CEN Lian. Preparation and characterization of PLGA microspheres by microfluidics method. Modern Chemical Industry, 2018, 38(1): 129-132.
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http://www.xdhg.com.cn/CN/10.16606/j.cnki.issn0253-4320.2018.01.030  或          http://www.xdhg.com.cn/CN/Y2018/V38/I1/129
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