Abstract: A new series of thiourea based small molecular catalysts with multi hydrogen donor is designed and synthesized.These catalysts can be used in the asymmetric Michael addition reaction between malononitrile and nitro styrene,leading to a yield of 79% and an ee value of 11%.The catalysts show a similarity to the specificity of enzyme catalysis in catalyzing asymmetric Michael addition reaction,and only the catalysts that have consistent structure in multi chiral centers show catalytic property.
马淑敏, 张晶, 陈立功, 闫喜龙, 李阳. 新型硫脲类小分子催化剂的合成与应用[J]. 现代化工, 2017, 37(12): 153-157.
MA Shu-min, ZHANG Jing, CHEN Li-gong, YAN Xi-long, LI Yang. Synthesis and application of novel thiourea based small molecule catalysts. Modern Chemical Industry, 2017, 37(12): 153-157.
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